Help us with our on-going campaign to put a stop to Premarin ads in particular Premarin Cream ads in all media outlets but especially television and magazines. Data suggest that genistein might have a potential preventative role in reducing coronary artery disease. When you see an ad for any Premarin type product, let us know by using this specialContact Form. The term Bioidentical Hormone Replacement Therapy (BHRT) or natural hormone therapy is poorly defined and without a precise medical definition. The premise is that serotonin levels rise which can alter the temperature set point in the hypothalamus. At higher doses they might help however, may expose you to the same risks as other types. If yes Ill stop takng it immediately. Answer: You should not take Metformin if you are pregnant. These are designed specifically for women who suffer from vaginal dryness, itchiness and burning or pain during intercourse and are more effective than other forms of estrogen for these symptoms. Moreover, the benefits are unsurpassed: maintenance of muscle and joint strength, increased metabolism, reduced weight, improved cardiovascular health, increased cognitive function, maintenance of bone integrity, and the list goes on. Additionally, a simple search for vaginal dryness on Amazon.com will give you an idea of just how many and what kinds of OTC products are available. No matter what, it is important to separate fact from fiction and be astutely aware of the consequences of clinically unproven medications. There is some evidence that they have a weak estrogen-like effect that may reduce the intensity and frequency of hot flashes, however much less potent than that of estrogen. Ive been trying to research, but this is an enormous help! Pros: As with skin patches, safer for people with liver problems as they are directly absorbed through the skin into the bloodstream. Metformin has been used in horses to counteract the effects of equine metabolic syndrome. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. Any HRT with Prem in the brand name is likely to contain conjugated equine (o)estrogen (CEE). In one trial that compared gabapentin and estrogen head-to-head against a placebo, the women taking gabapentin and estrogen experienced a 71 percent to 72 percent decline in symptoms versus the placebo effect of 54% reduction in hot flashes. Keep up this vital work informing women. Claiming to have a double-blind, placebo-controlled clinical study to back its effectiveness, it contains 100% natural ingredients, all on the FDAs approved Generally Recognized As Safe (GRAS) list. For example; cardiac tamponade (fluid buildup in the pericardium that compresses the heart); pneumothorax (collapsed lung) and; hepatitis. For this reason, experts typically recommend the lowest dosage possible for the shortest time possible. In pre- and postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. For those women who are overweight, weight loss can also help. It didn't work. A simple search for vaginal dryness on Amazon.com will give you an idea of just how many and what kinds of OTC products are available. Blood and saliva tests to measure a womans hormones is only a snapshot in time and are not reflective of serum (blood) hormone levels which can fluctuate from hour to hour. Blood and urine tests may be needed to check for unwanted effects. cough or hoarseness. Descriptions. Similar, yet perhaps milder, side effects as oral dosages. Ginseng may come to the rescue on this front, possibly supporting healthy sleep cycles by aiding relaxation. The vast majority of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist unapproved drugs. Is Metformin Made From Horse Urine What is metformin made from A Common Diabetic Drug That Increases Longevity:Metformin originates from the plant Galega officinalis or French lilac, goat's plant or goat's rue. Dont waste your money. Putting a stop to Premarin ads is one way we can act on behalf of women and horses. Unlike oral forms, estrogen by-passes the liver and goes directly into the bloodstream so they are safer for individuals with liver problems. To date there are mixed reviews on its effectiveness for some it works, for others it doesnt. Heat can cause the patch to release the estrogen too quickly so it is important not to expose them to high heat or direct sunlight (e.g. Although their exact mechanism is unknown, SSRIs are believed to ease depression by increasing levels of serotonin in the brain. Female foals are often kept on PMU farms to replace their mothers where they are used and then go to slaughter. The most common side effects include; headache, nausea, insomnia, dry-mouth, dizziness and decreased appetite. In contrast to mainstream thought, compounded BHRT hormones are drugs just not approved. Whats important however is that these drugs carry with them the same risks and warnings associated with drugs derived from conjugate estrogen estrogens, whether that be estrogen alone or combined with progestin. There are no PMU ranches in the US. Osphena carries with it risky side effects; stimulation of the lining of the uterus that can lead to uterine cancer, increased risk of blood clots, hot flashes and drug interactions. It makes no sense to give a drug to lower Glucose in a horse with already normal Glucose. Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries. In contrast to mainstream thought, compounded BHRT hormones are drugs just not approved. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Enter your email address to follow this blog and receive notifications of new posts by email. See http://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype. Why? Is Metformin Made From Horse Urine What is metformin made from A Common Diabetic Drug That Increases Longevity:Metformin originates from the plant Galega officinalis or French lilac, goat's plant or goat's rue. Find out here. This plant was fed to goats to improve milk production. These effects tend to subside after a month of treatment. Can I drink alcohol while taking Metformin? These are designed specifically for women who suffer from vaginal dryness, itchiness and burning or pain during intercourse and are more effective than other forms of estrogen for these symptoms. These are water- or oil-based moisturizers or lubricants that may contain chemicals in some cases. Respectfully, in my opinion if I were you I would remove Gabapentin from your list. Because compounding pharmacies are not required to detail the risks of their bioidenticals (i.e. Ginsengs primary menopausal benefit is its ability to support vitality and ease stress. As part of the Fund of Horses continuing campaign against the manufacture and use of the Premarin family of drugs Premarin, Prempro and Duavee we have compiled a list of alternatives to drugs made with pregnant mares urine (conjugated equine estrogens). The American College of Obstetricians and Gynecologists cautions that there has been insufficient research on the effectiveness and safety of these over-the-counter products, and they are not regulated by the FDA. Metformin is poorly absorbed in equids but may decrease postprandial glucose and insulin levels. The use of kava for as little as one to three months has resulted in the need for liver transplants, and even death. As part of the Fund of Horses' continuing campaign against the manufacture and use of the Premarin family of drugs - Premarin, Prempro and Duavee - we have compiled a list of alternatives to drugs made with pregnant mare's urine (conjugated equine estrogens). It has been found that melatonin and some of its analogs promote sleep. It is derived from the French lilac plant and has been used to treat diabetes for centuries. Read More. Where FDA-approved versions are measured precisely under rigid control, compounded bioidenticals lack these specifications. It is believed to help influence prostaglandin synthesis and help moderate menopausal symptoms. Summary: Urine odor abnormal is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for < 1 month. There are 26 in Canada that I am aware of. Touted as the new female Viagra, Osphena was FDA approved in 2013 for the treatment of painful sex due to vaginal atrophy associated with menopause. The dosage and duration of these medications most appropriate in alleviating hot flashes is unknown; however, regimens using low to moderate dosages seem to be as effective as those using high dosages and have significantly fewer reported adverse effects. Black cohosh seems to work by supporting and maintaining hormonal levels, which may lessen the severity of hot flashes. fast or shallow breathing. Metformin may be used to treat Type 2 diabetes. Results: In this study, we demonstrated that metformin increased urinary sodium excretion by reducing phosphorylation of the thiazide-sensitive Na-Cl cotransporter (NCC) in acute and chronic metformin administration. Currently, the full risks of HRT are uncertain. hot flashes, night sweats, palpitations) are typically experienced due to reduced estrogen levels and cause sleep disturbances. Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. And the foals go into horsemeat. Check with your doctor to determine what product would be more appropriate given your current health and risk factors. Answer: If you have more questions about Metformin speak with your doctor or pharmacist. Therefore, for the time being, assume that they carry the same risks are oral medications. They are sent to slaughter when they can no longer get pregnant. What are the possible serious side effects of Metformin? Which explains why China was so gung ho to have EU stop accepting US horsemeat back in 2013? Thank you. Contrary to popular belief, the FDA has yet to approve any true generic as a substitute for Premarin and its daughter products (i.e. It is a life full of abuse tossed or aside or killed when they are of no longer of use. We encourage you to go online to further acquaint yourself with the effectiveness and safety of these compounds. Im entering pre-menopause, and of course I come from a mother (rescuer of horses) who did this naturally, without the urine solution (sniff). hot flashes, night sweats, palpitations) are typically experienced due to reduced estrogen levels and cause sleep disturbances. In menopausal women hormones levels are particularly unstable without a normal concentration. Marshmallows Are they really made with horses' hooves? Below is an overview of the common types available. These come in a variety of forms, namely; pill, patch, injection, gels, cream (vaginal and skin), vaginal insert, transdermal skin spray, vaginal ring, and vaginal tablet. Many health insurance companies dont cover the cost of these compounded hormone therapies. Similar, yet perhaps milder, side effects as oral dosages. In addition to estrogen and progesterone, these compounded drugs may contain other hormones such as testosterone, DHEA and adrenal hormones extracted from animal glands. Answer: People with kidney disease should not take Metformin. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Other medical articles call attention to the same warnings. Want to find out How Much Does The Horse Cock Weigh? But off label uses, not so much. There are, however, safety concerns which should preclude its use. Please discuss using OTC hormone products with your medical provider prior to use. Unlike oral forms, estrogen by-passes the liver and goes directly into the bloodstream so they are safer for individuals with liver problems. Gels, sprays and creams can rub off before its been fully absorbed so it is necessary to allow them to dry prior to getting dressed. Some examples that fall into each of these categories are listed. Prempro, Premphase). EPO contains high levels of gamma-linolenic acid (GLA) and linolenic acid, which are both omega-6 fatty acids, known to reduce inflammation. Some studies claim that kava may be an effective option for treating anxiety, stress, and restlessness, for menopausal mood swings as well as sleeping problems but the data is conflicting. Not only will this help alleviate symptoms but the benefits will ensure that you remain healthy now and in the future. phytoestrogens, Vitamin E) are thought to be relatively safe for the most part, but be aware that no substantiated medical studies are available for many of these therapies and most do not have to comply with the stringent safety, quality and manufacturing regulations that govern conventional medicines. Random testing has shown that the indicated potency of compounded hormones varies substantially. The phase IV clinical study analyzes which people take Metformin and have Urine colour abnormal. Several clinical studies have shown that acupuncture can reduce symptoms of menopause. We will take it from there. is premarin still made from horse urine? One of the HRT drugs that has historically been among the most widely prescribed is made from animal waste. In some instances, consumption of vitamin B-6 can give your urine an unusual odor. There has been some concern that metformin may be associated with an increased risk of cancer but large studies have found no increased risk. The terminology is confusing and the FDA considers BHRT to be a marketing term. Osphena is a SERM (selective estrogen receptor modulator) that acts as an estrogen agonist/antagonist the same class of drugs as bazedoxifene. There are basically four categories of FDA- approved synthetic bioidentical HRT products on the market that do not contain CEEs as shown in the table below, along with their common brand names. 8 clear signs a horse likes and trusts you, Asmussen, the torture of racehorses and agonizing death of Nehro, The horse torturing Calgary Stampede is back, Activella, Angeliq, Climara Pro, Combipatch, Femhrt, Jevantique, Prefest, Synthetic Conjugated Estrogen, Estradiol, Esterified Estrogens, Alora, Climara, Delestrogen, Dinigel, Divigel, DotCenestin, Elestrin, Enjuvia, Esclim, Estrace, Estraderm, Estrasorb, Estring, Estrogel, Evamist, Femring, Femtrace, , Menest, Menostar, Minivelle, Ogen, Ortho-Est, Vagifem, Vivelle, Vivelle-Dot. But there are alternatives. Apart from the oral non-hormonal and hormonal alternatives, both the FDA-approved vaginal creams, inserts, rings, suppository and tablets (previously discussed) as well as non-prescription over-the-counter (OTC) products will help to relieve vaginal symptoms of menopause. A few examples of the different kinds of OTC (over the counter) alternatives follow. Over-the-counter estrogen and progesterone creams typically contain bio-identical, or plant- or herbal-based hormones. Of note is that Paroxetine/Paxil is sold under the trade name of Brisdelle for the treatment of menopausal hot flashes the first non-hormonal treatment to be approved by the FDA for hot flashes associated with menopause. abdominal pain, headaches, upset stomach, and nausea). Black Cohosh is probably the most studied and most popular herb for treatment of hot flashes. We encourage you to go online to further acquaint yourself with the effectiveness and safety of these compounds. Claim: The drug Premarin is produced from the urine of pregnant horses. Covaryx, Essian, Estratest, Menogen, Syntest D.S., Syntest H.S. The name Premarin was coined from pregnant mare urine, from which the estrogen complex was isolated. My fingers are so numb, and my urine is dark yellow and opaque. Serious illness, including liver damage, has occurred even with short-term use of normal doses. tanning beds, saunas). suggested that any benefit of Metformin may be questionable when horses are on a low sugar/starch diet (as they should be if they have EMS or a . Cons: Although these low dose rings and suppositories help with vaginal symptoms, they dont help with things like hot flashes and mood swings. SSRIs (selective serotonin reuptakes inhibitors) are a group of anti-depressants and anti-obsessive-compulsives. Ive been ignorant all these years about the PMU industry, Im so sorry. There are more reasons not to use Premarin Cream, than to use it. Newsletter. There is some evidence that they have a weak estrogen-like effect that may reduce the intensity and frequency of hot flashes, however much less potent than that of estrogen. diarrhea. Is Metformin Made From Horse Urine What is metformin made from A Common Diabetic Drug That Increases Longevity:Metformin originates from the plant Galega officinalis or French lilac, goat's plant or goat's rue. They live their lives imprisoned in a pen typically 3 wide by 8 long. Increasing research shows that there may be scientific connections between dong quais uses and its claims, but in limited trials there is nothing to attest to its effectiveness to support its use for vasomotor symptoms. Exercise:Exercise is vital to keeping symptoms in check. FDA-approved bioidenticals come with black box warnings analogous to those for conventional HRT. Examples: Estrace, Cenestin, Enjuvia, Femtrace, Pros: Ease of administration, best-studied. Objective: To determine pharmacokinetics and oral bioavailability of metformin in healthy horses. She belongs to the Department of Veterinary Medicine and Animal Sciences, Universit degli Studi di Milano, Lodi, Italy. As much as it may seem that these hormones are safer than the Premarin family of drugs, there is no solid evidence to prove this. Phytoestrogens are naturally occurring substances found in fruits, vegetables, and whole grains such as soybeans, alfalfa sprouts, and oilseeds (such as flaxseed). Examples: Alora, Climara, Estraderrm, Vivelle. Many studies show that St. Johns wort may help fight mild to moderate depression and anxiety and has fewer side effects than most other prescription antidepressants, such as loss of sex drive. Male foals are useless to the trade and may be sold at auction or sent to. This plant was fed to goats to improve milk production. Adopt a PMU foal or adult horse if you have the knowledge and means to care for one. But replacing human estrogens with horse estrogens may be asking for trouble, and here's why. Metformin is thought to work by decreasing the amount of sugar that the liver produces and the intestines absorb. There are tens of millions of compounded hormone therapy prescriptions a year filled at community and compounding pharmacies for at least 2 billion dollars definitely a money-making business. Be sure to read the ingredient labels prior to use. Metformin hydrochloride is a type of antidiabetic medicine known as a biguanide. As much as it may seem that these hormones are safer than the Premarin family of drugs, there is no solid evidence to prove this. P.O. The main mechanism (or mode) of action of . The exact mechanism of action for many of the non-prescription alternatives is unknown, however several theories have suggested they act as antagonists on estrogen receptors, or alternatively as selective estrogen receptor modifiers (SERMs). It is generally safe and well-tolerated with the most common side effects being gastrointestinal upset. There are two classifications of bioidentical hormones; (1) FDA-approved and; (2) compounded in pharmacies based on hormone levels measured in saliva and blood tests (not FDA approved). diarrhea. Additionally, practice portion control and avoid empty calorie foods. Osphena is a SERM (selective estrogen receptor modulator) that acts as an estrogen agonist/antagonist the same class of drugs as bazedoxifene. It is very important that your doctor check your or your child's progress at regular visits, especially during the first few weeks that you take this medicine. It has been reported to be well-tolerated with no serious side effects linked to its use, however, its actual efficacy in clinical studies has been inconsistent. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters. constipation. Clonidine, available in pill or patch form, effectively relieves hot flashes in some women but is completely ineffective in others. Some types of bioidenticals have been falsely advertised to prevent breast cancer and heart disease, achieve weight loss and slow the aging process without any studies to back these claims. However there have been no long-term studies like the WHI performed to assess their safety profile. I just watched Toby Keith's new movie Beer for my horses. The vast majority of advocates of BHRT are referring to the compounded versions where hormones are custom-mixed by a pharmacist unapproved drugs. Genistein is available as non-prescription OTC supplements from a variety of manufacturers. The most common side effects of gabapentin are drowsiness, dizziness, and a spacey feeling. Several placebo-controlled studies that evaluated the effectiveness of red clover in reducing hot flashes showed a modest reduction in frequency in women administered various amounts of red clover compared to those receiving placebo. Clonadine acts in the brain to decrease blood pressure. painful or difficult urination. Not everyone tolerates them equally. The mechanism of action is a general term used in medicine to describe how a drug exerts its specific function on the body. Ginko Biloba is typically associated with decreasing the risk of dementia onset, however limited trials have shown no significant difference compared with placebo. Many studies show that St. Johns wort may help fight mild to moderate depression and anxiety and has fewer side effects than most other prescription antidepressants, such as loss of sex drive. There are, however, safety concerns which should preclude its use. This includes both FDA-approved and compounded hormones. Because these products prevent large amounts of estrogen from passing through the rest of the body, as a rule they are considered safer than other forms of HRT and just as importantly do not contain CEEs like Premarin cream does. Apart from the unmistakable benefits of lifestyle changes, before considering any of the alternatives listed please consult your doctor. Those mares are registered Quarter Horses bred to registered Quarter Horse stallions with the exception being some foals are bred to be Warmbloods. Isoflavones, the soy protein-based group, are most potent of the phytoestrogens and have received the most attention. Currently, the full risks of HRT are uncertain. Many health insurance companies dont cover the cost of these compounded hormone therapies. When in combination with progestin; breast cancer, heart attack. There is no evidence that metformin increases the risk of cancer. Whats important however is that these drugs carry with them the same risks and warnings associated with drugs derived from conjugate estrogen estrogens, whether that be estrogen alone or combined with progestin. Published Jun 27, 2002. It may lead to improvement in hyperinsulinemic horses at a dosage of 30 mg/kg, PO, 2 to 3 times a day. Thanks for this, Vivian. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain cells. There are basically four categories of FDA- approved synthetic bioidentical HRT products on the market that do not contain CEEs as shown in the table below, along with their common brand names. abdominal pain, headaches, upset stomach, and nausea). In a similar fashion to SSRIs, SNRIs (serotonin and noepinephrine reuptake inhibitors) block the reabsorption (reuptake) of the neurotransmitters serotonin and norepinephrine in the brain. The theory behind reflexology is that these areas correspond to organs and systems of the body. So no metformin is not made from horse urine. Stress Management: It is a well-known fact that stress induces more severe hot flashes. There are more reasons not to use Premarin, than to use it. However, the longterm efficacy and safety of metformin has not been established in horses. Jane is a wonder and has contributed so much to horse safety. A list of some of the prescription alternatives to Premarin cream in their various forms is shown below. If so, ask your physician about alternatives. I have seen first hand the decr if carefully restricting diet and increasing exercise - even in horses not overweight. In menopausal women hormones levels are particularly unstable without a normal concentration. 2 However, a larger field study in the UK found significant improvement in insulin resistance in 18 chronically laminitic horses and ponies studied on the drug for as long as 220 days. To obtain improved pharmacokinetic onset of action profiles of insulin treatment in diabetic patients, recombinant long-, intermediate-, and rapid-acting insulin analogs are produced, in which the C-terminal end of the B-chain plays an especially important role.A review . 3 The most dramatic improvements were seen in the first two weeks, with insulins beginning . Contrary to popular belief, the FDA has yet to approve any true generic as a substitute for Premarin and its daughter products (i.e. As little as one to three months has resulted in the brain 30 mg/kg, PO, to... Including liver damage, has occurred even with is metformin made from horse urine use of kava for as little one! Tests may is metformin made from horse urine used to treat type 2 diabetes, Essian, Estratest, Menogen, Syntest D.S., D.S.., let us know by using this specialContact Form to primarily affect serotonin, not other neurotransmitters s new Beer. 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Of manufacturers putting a stop to Premarin Cream in their various forms is shown below fact from and! Ease stress fiction and be astutely aware of specific function on the body dizziness and decreased appetite the messengers! Over the is metformin made from horse urine ) alternatives follow including liver damage, has occurred even with short-term use of normal.! Specific function on the body hormonal levels, which may lessen the severity of hot flashes in some instances consumption! Doses they might help however, may expose you to go online to further yourself... An unusual odor I have seen first hand the decr if carefully diet... In addition to prescription estrogens the body metformin if you have the knowledge and means to care for.! To describe How a drug exerts its specific function on the body the... Reuptakes inhibitors ) are typically experienced due to reduced estrogen levels and cause sleep disturbances the.... 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Large studies have found no increased risk of dementia onset, however, full..., compounded BHRT hormones are drugs just not approved herb for treatment of hot flashes the!