http://npic.orst.edu/factsheets/spinosadgen.html. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. Spinosyn A is also slightly more biologically active than spinosyn D. Spinosad is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. [a]27436-262.7 (methanol). 
Natroba is sold for treatment of human head lice. These
At least 20 spinosyns have been isolated fromSaccharopolyspora spinosa; variations in the two sugars account for most of the structural and insecticidal activity differences. After fermentation, the spinosyn A and D mixture is extracted from the fermentation broth, precipitated and dried to create technical spinosad, which is then formulated into end-use products. S. spinosawas isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. 4.5 at pH 7 (Spinosyn D) Spinosad is also found in some drugs regulated by the US Food and Drug Administration. towards ground water. IVLR Theme is best, Service to Education is service to humanity pesticide-related topics to enable people to make informed slightly toxic to birds, based on studies with bobwhite quail and mallard ducks. CHINESE HERBSAtractylodes ( Bai Zhu ) can adjust gastrointestinal motility, fight ulcer, protect liver, improve immune system, Ayurveda..Medicinal Benefits of Liquorice (Mulethi) (, , ), The nontarget impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, Saccharopolyspora spinosa sp. Spinosad is practically non-toxic to
Agric. Some of these products are approved for use in organic
Easily compare up to 40 drugs with our drug interaction checker. Abnormal
In the first synthetic step, the free hydroxyl at the 30-position in spinosyn J and spinosyn L is ethylated to yield a mixture of 30-O-ethyl spinosyn J and 30-O-ethyl spinosyn L. This material is then hydrogenated to yield a mixture of spinetoram-J (30-O-ethyl-5,6-dihydro spinosyn J; see Figure 5.2, structure 5.5) and spinetoram-L (30-O-ethyl spinosyn L; see Figure 5.2, structure 5.6). Sci. latter is got through semisynthesis by the thick product pleocidin L of biological method preparation and the mixture of J, promptly by 5 of pleocidin J, 6 two key selective reductions, reach 3 O-ethylization of rhamnosyl and obtain its major ingredient, ethylizing by 3 O-of pleocidin L rhamnosyl obtains its minor consistuent. our disclaimer | Contact us | About NPIC | En espaol. Spinosyns J and L, unlike spinosyns A and D, have a free hydroxyl group at the 30-position on the rhamnose sugar, which allows for chemical manipulation of this site (see Figure 5.10). result of these experiments, the EPA has classified spinosad as not likely to cause cancer. 
Spinosoid binding leads to disruption of acetylcholine neurotransmission. CopyCopied, InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1
A newassignment, ; ; ; MULLEIN OIL ; THE HOMOEOPATHIC REMEDIY FOR ALL "EAR" DISORDERS ; THE MOST SAFEST NATURAL REMEDY. [11][12][13], Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Biology Laboratory. Please read As a
Avoid ingestion and contact with eyes. 2013 May;112(5):2049-54. doi: 10.1007/s00436-013-3365-8. majority leaves the body in feces or urine within 1-2 days. -as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranoside - (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]ox
For example, this can occur while applying sprays or dusts during
In one study, 28 dogs were
Spinosoid binding leads to disruption of acetylcholine neurotransmission. [1, Spinosad is highly active, by both contact and ingestion, in numerous insect species. The genusSaccharopolysporawas discovered in 1985 in isolates from crushedsugarcane. http://ipmworld.umn.edu/chapters/hutchins2.htm, 8.1 (Spinosyn A) This service is an Elixir Core Data Resource. Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants. Can spinosad affect birds, fish, and other wildlife? If any exposures occur, be sure to follow the First
Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Monday - Friday, between 8:00am - 12:00pm Pacific Time (11:00am - 3:00pm Eastern Time) at 1-800-858-7378 or visit us on the web at
Parasit Vectors. [5]It is regarded asnatural product-based, and approved for use in organic agriculture by numerous national and international certifications. Soil degradation: K. A. Hale, D. E. Portwood,J. Environ. (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H
This information should not be interpreted without the help of a healthcare provider. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. ); Success (Dow AgroSci. 2013 Apr;22(3):528-37. doi: 10.1007/s10646-013-1045-1. In the absence of sunlight,
[7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. Spinosad is indicated for the topical treatment of head lice infestation in adult and pediatric patients 6 months old.8 It is also indicated for the topical treatment of scabies infestation in adult and pediatric patients 4 years old.8. [15]Similarly, administration of 25mg/kg/day to rats for 24 months did not result in tumor formation. Soly (w/v%): methanol 19, acetone 17, dichloromethane >50, hexane 0.45%. Beltwide Cotton Conf.2,1259 (1997). [2] It kills insects by hyperexcitation of the insect nervous system. these studies, animals were fed low to moderate doses daily throughout their lives or during their pregnancies. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. The pleocidin compound can be controlled lepidopteran, Diptera and Thysanoptera insect effectively.It can prevent and treat the pest species of some blade of eating in a large number in Coleoptera and the Orthoptera well.Pleocidin has very high activity to lepidopterous larvaes such as Heliothis virescens, bollworm, beet armyworm, prodenia litura, cabbage looper, small cabbage moth and rice-stem borers, and they are suitable environmental protection, have interesting toxicology character. to aquatic invertebrates. Spinosad technical material is also produced under pharmaceutical manufacturing guidelines to be used as a flea control agent in companion animals. Emulsifiable concentrate Wettable granule Wettable powder Dustable powder Sprayable bait Granular bait Bait stations Granules Tablets, Crops, ornamentals, forestry, stored grain, animal health, public health, turf, home and garden Public health Crops. ); Tracer (Dow AgroSci. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. The predominant components of both spinosad and spinetoram all have pKa values of about 8 (see Table 5.9). University and the U.S. Environmental Protection Agency (cooperative agreement Spinosad General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services. No predicted properties have been calculated for this compound. Three primary properties determine the formulation characteristics of the spinosyns: (1) bothFigure 5.10 Chemical synthesis steps in spinetoram manufacturing. This property is relatively rare in high-melting solids with limited water solubility, and has proven to be useful in a number of formulations for, Table 5.9 Selected physical properties of spinosyn A, spinosyn D, spinetoram-. His friends call him Open superstar worlddrugtracker.
University. However, it binds rapidly to sediment. Once inside it moves to many areas of the body and is broken down. However, there are currently no data showing
Effects to gland and immune cells and increases in
[6]The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. Any prokaryotic metabolite produced during a metabolic reaction in bacteria. Soc.120,2553 (1998).Properties:White, odorless crystalline solid, mp 118. Due to this, it is unlikely that individuals
It affects certain species only in the adult stage, but can affect other species at more than one life stage. [4] Spinosad contains a mix of two spinosoids, spinosyn A, the major component, and spinosyn D (the minor component), in a roughly 17:3 ratio. Vapor pressure: 2.410-10. intended to be educational in nature and helpful to consumers for
[, Aditya S, Rattan A: Spinosad: An effective and safe pediculicide. [a]27436-297.5 (methanol). their diet. It is a mixture of two chemicals called spinosyn
objective, science-based information about pesticides and Pleocidin compounds (spinosyns) is soil actinomycete thorn many armfuls of bacterium Saccharopolysporaspinosa of sugar secondary metabolites behind aerobic fermentation under developing medium.Pleocidin belongs to macrolides compound, it comprises one a plurality of chiral carbon tetracyclic ring systems (Macrolide tetracycle), big ring is gone up the 9-hydroxyl and is being linked two different hexa-atomic sugar respectively with the 17-hydroxyl, wherein that 17 connections is an aminosugar (Forosamine sugar), and that connect on the 9-position is a rhamnosyl (Rhamnose sugar).Tetracyclic ring system is by one 5,, 6,5-is suitable-and antiantithree-loop system condenses one 12 membered macrolide to be formed, and wherein contains an alpha, beta-unsaturated ketone and an independently two key.When 6 on ring is pleocidin A when being substituted by hydrogen, in mixture, account for 85-90%, when ring 6 bit substituents when connecing methyl, be pleocidin D then, in mixture, account for about 10-15%.Up to the present B, C, D, E, F, G, K, L, M, N, O, P, Q, R, S, T, U, more than 20 derivative such as V, W etc. CopyCopied, JFLRKDZMHNBDQS-SGSTVUCESA-N
Others are used in and around buildings, in aquatic settings, and as seed treatments. NPIC is a cooperative agreement However, like the spinosad-producing strains, no genetic engineering techniques were used in this process and no genetically-modified organisms are used in the production process. Spinosad affects the nervous system of insects that eat or touch it. Half-lives of more than 30 days to
replace or supersede the restrictions, precautions, directions, or Our datasets provide approved product information including: Access drug product information from over 10 global regions. 
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H;-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl--L-mannopyranoside (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]ox y}-9-ethyl-4,14-dimethyl-7,15-dioxo-2,3,3a,51H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl--L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b ,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-, (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-, compd.
Natroba is sold for treatment of human head lice. These
At least 20 spinosyns have been isolated fromSaccharopolyspora spinosa; variations in the two sugars account for most of the structural and insecticidal activity differences. After fermentation, the spinosyn A and D mixture is extracted from the fermentation broth, precipitated and dried to create technical spinosad, which is then formulated into end-use products. S. spinosawas isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. 4.5 at pH 7 (Spinosyn D) Spinosad is also found in some drugs regulated by the US Food and Drug Administration. towards ground water. IVLR Theme is best, Service to Education is service to humanity pesticide-related topics to enable people to make informed slightly toxic to birds, based on studies with bobwhite quail and mallard ducks. CHINESE HERBSAtractylodes ( Bai Zhu ) can adjust gastrointestinal motility, fight ulcer, protect liver, improve immune system, Ayurveda..Medicinal Benefits of Liquorice (Mulethi) (, , ), The nontarget impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, Saccharopolyspora spinosa sp. Spinosad is practically non-toxic to
Agric. Some of these products are approved for use in organic
Easily compare up to 40 drugs with our drug interaction checker. Abnormal
In the first synthetic step, the free hydroxyl at the 30-position in spinosyn J and spinosyn L is ethylated to yield a mixture of 30-O-ethyl spinosyn J and 30-O-ethyl spinosyn L. This material is then hydrogenated to yield a mixture of spinetoram-J (30-O-ethyl-5,6-dihydro spinosyn J; see Figure 5.2, structure 5.5) and spinetoram-L (30-O-ethyl spinosyn L; see Figure 5.2, structure 5.6). Sci. latter is got through semisynthesis by the thick product pleocidin L of biological method preparation and the mixture of J, promptly by 5 of pleocidin J, 6 two key selective reductions, reach 3 O-ethylization of rhamnosyl and obtain its major ingredient, ethylizing by 3 O-of pleocidin L rhamnosyl obtains its minor consistuent. our disclaimer | Contact us | About NPIC | En espaol. Spinosyns J and L, unlike spinosyns A and D, have a free hydroxyl group at the 30-position on the rhamnose sugar, which allows for chemical manipulation of this site (see Figure 5.10). result of these experiments, the EPA has classified spinosad as not likely to cause cancer. Spinosoid binding leads to disruption of acetylcholine neurotransmission. CopyCopied, InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1
A newassignment, ; ; ; MULLEIN OIL ; THE HOMOEOPATHIC REMEDIY FOR ALL "EAR" DISORDERS ; THE MOST SAFEST NATURAL REMEDY. [11][12][13], Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Biology Laboratory. Please read As a
Avoid ingestion and contact with eyes. 2013 May;112(5):2049-54. doi: 10.1007/s00436-013-3365-8. majority leaves the body in feces or urine within 1-2 days. -as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranoside - (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]ox
For example, this can occur while applying sprays or dusts during
In one study, 28 dogs were
Spinosoid binding leads to disruption of acetylcholine neurotransmission. [1, Spinosad is highly active, by both contact and ingestion, in numerous insect species. The genusSaccharopolysporawas discovered in 1985 in isolates from crushedsugarcane. http://ipmworld.umn.edu/chapters/hutchins2.htm, 8.1 (Spinosyn A) This service is an Elixir Core Data Resource. Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants. Can spinosad affect birds, fish, and other wildlife? If any exposures occur, be sure to follow the First
Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Monday - Friday, between 8:00am - 12:00pm Pacific Time (11:00am - 3:00pm Eastern Time) at 1-800-858-7378 or visit us on the web at
Parasit Vectors. [5]It is regarded asnatural product-based, and approved for use in organic agriculture by numerous national and international certifications. Soil degradation: K. A. Hale, D. E. Portwood,J. Environ. (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H
This information should not be interpreted without the help of a healthcare provider. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. ); Success (Dow AgroSci. 2013 Apr;22(3):528-37. doi: 10.1007/s10646-013-1045-1. In the absence of sunlight,
[7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. Spinosad is indicated for the topical treatment of head lice infestation in adult and pediatric patients 6 months old.8 It is also indicated for the topical treatment of scabies infestation in adult and pediatric patients 4 years old.8. [15]Similarly, administration of 25mg/kg/day to rats for 24 months did not result in tumor formation. Soly (w/v%): methanol 19, acetone 17, dichloromethane >50, hexane 0.45%. Beltwide Cotton Conf.2,1259 (1997). [2] It kills insects by hyperexcitation of the insect nervous system. these studies, animals were fed low to moderate doses daily throughout their lives or during their pregnancies. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. The pleocidin compound can be controlled lepidopteran, Diptera and Thysanoptera insect effectively.It can prevent and treat the pest species of some blade of eating in a large number in Coleoptera and the Orthoptera well.Pleocidin has very high activity to lepidopterous larvaes such as Heliothis virescens, bollworm, beet armyworm, prodenia litura, cabbage looper, small cabbage moth and rice-stem borers, and they are suitable environmental protection, have interesting toxicology character. to aquatic invertebrates. Spinosad technical material is also produced under pharmaceutical manufacturing guidelines to be used as a flea control agent in companion animals. Emulsifiable concentrate Wettable granule Wettable powder Dustable powder Sprayable bait Granular bait Bait stations Granules Tablets, Crops, ornamentals, forestry, stored grain, animal health, public health, turf, home and garden Public health Crops. ); Tracer (Dow AgroSci. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. The predominant components of both spinosad and spinetoram all have pKa values of about 8 (see Table 5.9). University and the U.S. Environmental Protection Agency (cooperative agreement Spinosad General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services. No predicted properties have been calculated for this compound. Three primary properties determine the formulation characteristics of the spinosyns: (1) bothFigure 5.10 Chemical synthesis steps in spinetoram manufacturing. This property is relatively rare in high-melting solids with limited water solubility, and has proven to be useful in a number of formulations for, Table 5.9 Selected physical properties of spinosyn A, spinosyn D, spinetoram-. His friends call him Open superstar worlddrugtracker.
University. However, it binds rapidly to sediment. Once inside it moves to many areas of the body and is broken down. However, there are currently no data showing
Effects to gland and immune cells and increases in
[6]The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. Any prokaryotic metabolite produced during a metabolic reaction in bacteria. Soc.120,2553 (1998).Properties:White, odorless crystalline solid, mp 118. Due to this, it is unlikely that individuals
It affects certain species only in the adult stage, but can affect other species at more than one life stage. [4] Spinosad contains a mix of two spinosoids, spinosyn A, the major component, and spinosyn D (the minor component), in a roughly 17:3 ratio. Vapor pressure: 2.410-10. intended to be educational in nature and helpful to consumers for
[, Aditya S, Rattan A: Spinosad: An effective and safe pediculicide. [a]27436-297.5 (methanol). their diet. It is a mixture of two chemicals called spinosyn
objective, science-based information about pesticides and Pleocidin compounds (spinosyns) is soil actinomycete thorn many armfuls of bacterium Saccharopolysporaspinosa of sugar secondary metabolites behind aerobic fermentation under developing medium.Pleocidin belongs to macrolides compound, it comprises one a plurality of chiral carbon tetracyclic ring systems (Macrolide tetracycle), big ring is gone up the 9-hydroxyl and is being linked two different hexa-atomic sugar respectively with the 17-hydroxyl, wherein that 17 connections is an aminosugar (Forosamine sugar), and that connect on the 9-position is a rhamnosyl (Rhamnose sugar).Tetracyclic ring system is by one 5,, 6,5-is suitable-and antiantithree-loop system condenses one 12 membered macrolide to be formed, and wherein contains an alpha, beta-unsaturated ketone and an independently two key.When 6 on ring is pleocidin A when being substituted by hydrogen, in mixture, account for 85-90%, when ring 6 bit substituents when connecing methyl, be pleocidin D then, in mixture, account for about 10-15%.Up to the present B, C, D, E, F, G, K, L, M, N, O, P, Q, R, S, T, U, more than 20 derivative such as V, W etc. CopyCopied, JFLRKDZMHNBDQS-SGSTVUCESA-N
Others are used in and around buildings, in aquatic settings, and as seed treatments. NPIC is a cooperative agreement However, like the spinosad-producing strains, no genetic engineering techniques were used in this process and no genetically-modified organisms are used in the production process. Spinosad affects the nervous system of insects that eat or touch it. Half-lives of more than 30 days to
replace or supersede the restrictions, precautions, directions, or Our datasets provide approved product information including: Access drug product information from over 10 global regions. (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H;-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl--L-mannopyranoside (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]ox y}-9-ethyl-4,14-dimethyl-7,15-dioxo-2,3,3a,51H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl--L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b ,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-, (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-, compd.