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View abstract. Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., and Haskell, C. F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

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View abstract. Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., and Partridge, L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. 1998;123(8):1691-1699. It is used as a medicine. Sharma, M. and Gupta, Y. K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Grujic Milanovic, J., Mihailovic-Stanojevic, N., Miloradovic, Z., Jacevic, V., Milosavljevic, I., Milanovic, S., Ivanov, M., and Jovovic, D. J. RESVERATROL REDUCES BLOOD PRESSURE, CHANGES OF ANTIOXIDANT ENZYME ACTIVITY AND HISTOLOGICAL PARAMETERS IN EXPERIMENTAL MODEL OF MALIGNANT HYPERTENSION PP.29.171. Nature 8-5-2004;430(7000):686-689.

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In theory, taking resveratrol along with some medications that are broken down by the liver may increase the effects and side effects of some medications. Zou, J. G., Huang, Y. Basly, J. P., Marre-Fournier, F., Le Bail, J. C., Habrioux, G., and Chulia, A. J. Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. Piver, B., Berthou, F., Dreano, Y., and Lucas, D. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. View abstract. Gao X, Deeb D, Media J, et al.

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J Neuroophthalmol. Li W, Seifert M, Xu Y, Hock B. Almeida, L., Vaz-da-Silva, M., Falcao, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J. F., Nunes, T., Wright, L., and Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. View abstract. 10-1-2011;36(21):E1373-E1384. 6-7-2005;11(21):3171-3174. View abstract. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells.

And gone? Br.J.Cancer 3-4-2002;86(5):774-778. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. BMC Gastroenterol 2006;6:35. View abstract. Bioorg Med Chem 2004;12:5571-8. Biochem Biophys Res Commun 1999;254:739-43. Medicine & Science in Sports & Exercise 2011;43(5). View abstract.

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View abstract. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. A., and Alberts, D. S. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. 10-23-2012;8(5):790-793.

2014 Dec;12(10):497-501. J Nutr. Trincheri NF, Nicotra G, Follo C, et al. Nature 9-11-2003;425(6954):191-196. World J Gastroenterol. Neurosci.Lett. Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Aggarwal, B. View abstract. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells.

View abstract. View abstract. People use resveratrol for "hardening of the arteries" (atherosclerosis), lowering "bad" (LDL) cholesterol levels, increasing "good" (HDL) cholesterol levels, and preventing cancer and heart disease. Clin Chim Acta 1995;235:207-19.

Menopause. Kim YA, Choi BT, Lee YT, et al. View abstract. Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Curr Biol 2-7-2006;16(3):296-300. Oncol Rep 2004;11:441-6.

Some research suggests that resveratrol has weak estrogen (a female hormone) effects. Resveratrol might slow blood clotting. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.

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View abstract. Am J Clin Nutr. Mech.Ageing Dev 2007;128(10):546-552. Potter, G. A., Patterson, L. H., Wanogho, E., Perry, P. J., Butler, P. C., Ijaz, T., Ruparelia, K. C., Lamb, J. H., Farmer, P. B., Stanley, L. A., and Burke, M. D. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Curr Med Res Opin. Wuertz, K., Quero, L., Sekiguchi, M., Klawitter, M., Nerlich, A., Konno, S., Kikuchi, S., and Boos, N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. 9-15-2000;381(2):253-263. Molnar, V. and Garai, J. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Resveratrol might reduce levels of sugar (glucose) in the blood and help the body fight against disease. View abstract. View abstract. 2010;19(4):1359-1370. 2008;48(3):709-714.

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Murias M, Handler N, Erker T, et al. Some people apply resveratrol to their skin to treat acne. Baur, J. Schriever C, Pendland SL, Mahady GB.

Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Ziegler CC, Rainwater L, Whelan J, McEntee MF. 2000;51(3):513-520. However, some early research shows conflicting results. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. 2005 May 15;191(10):1719-29. Circulation 9-24-2002;106(13):1652-1658. Life Sci 11-10-2000;67(25):3103-3112. Resveratrol is a peroxidase mediated inactivator of COX-1 but not COX-2: A mechanistic approach to the design of COX-1 selective agents. J Alzheimers.Dis. Martin AR, Villegas I, La Casa C, de la Lastra CA. Boca Raton, FL: CRC Press, 2005. View abstract. Jannin, B., Menzel, M., Berlot, J. P., Delmas, D., Lancon, A., and Latruffe, N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Kozuki Y, Miura Y, Yagasaki K. Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action.Cancer Lett 2001;167:151-6. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Brasnyo, P., Molnar, G. A., Mohas, M., Marko, L., Laczy, B., Cseh, J., Mikolas, E., Szijarto, I. 2000;78(11):874-881. Steigerwald, M. D., Fisk, M. Z., Smoliga, J. M., and Rundell, K. W. Effects Of Resveratrol On Oxidative Stress And Vascular Function Following Exercise In Simulated Air Pollution: 2645. Ther.Adv.Respir.Dis. Dong, W., Li, N., Gao, D., Zhen, H., Zhang, X., and Li, F. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. 2001;37(3):262-270. Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays. Antiplatelet activity of cis-resveratrol.

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2012;50(3):179-87. Clin Hemorheol Microcirc. View abstract. Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. View abstract. Inflammation 2007;30:1-6. View abstract. Journal of Urology 2009;181(4):153-154. Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Xuzhu, G., Komai-Koma, M., Leung, B. P., Howe, H. S., McSharry, C., McInnes, I. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. View abstract. Int.Immunopharmacol. View abstract. Life Sci.

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A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. 1999;128(1):149-157.

Neurosci Lett 2003;351:83-6. Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., Iwasaki, M., Nishikawa, M., Iwasaka, T., and Das, D. K. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Burkitt, M. J. and Duncan, J. Ann.Rheum.Dis 2012;71(1):129-135. 8-15-2001;61(16):6137-6144.

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Knight, C. M., Gutierrez-Juarez, R., Lam, T. K., Arrieta-Cruz, I., Huang, L., Schwartz, G., Barzilai, N., and Rossetti, L. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. View abstract. Klink, J. C., Poulton, S., Antonelli, J., Potter, M. Q., Jayachandran, J., Tewari, A. K., Febbo, P. G., Pizzo, S. V., and Freedland, S. RESVERATROL ALTERS PROSTATE CANCER XENOGRAFT GROWTH: 724. Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. Cancer Res 10-1-2010;70(19):7392-7399. View abstract. Resveratrol in health and disease. Red wine, resveratrol, Chlamydia pneumoniae and the French connection. View abstract. View abstract. View abstract. 2012;67(12):1307-1312. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. View abstract.

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View abstract. Cancer Res 2004;64:696-703. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

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View abstract. View abstract. Ciolino, H. P. and Yeh, G. C. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Resveratrol might expand blood vessels and reduce the activity of cells important in blood clotting. J Nutr Biochem. Mokni M, Limam F, Elkahoui S, et al.

Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis 2007;28:922-31.