Glipizide: (Moderate) Antacids have been reported to increase the absorption of glipizide, enhancing its hypoglycemic effects. Acetaminophen; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Simultaneous administration should be avoided; separate dosing by at least 2 hours to limit an interaction. Do not exceed recommended daily dosage in any 24 hour period. In a study in healthy subjects, there was no significant change in nilotinib pharmacokinetics when an antacid (aluminum hydroxide/magnesium hydroxide/simethicone) was administered approximately 2 hours before or approximately 2 hours after a single 400-mg nilotinib dose. Antacid administration two hours after the sotalol dose does not alter sotalol pharmacokinetics or pharmacodynamics. The effect of the antacids in this regard is not expected to have a significant effect on the ability of ezetimibe to lower cholesterol. Staggering the times of administration may avoid this pharmacokinetic interaction. This interaction results in a 25% reduction in the bradycardic effect of sotalol (measured at rest). The safest first-line constipation treatments to use during pregnancy are those that are not absorbed systemically (e.g., fiber, bulk-forming laxatives, stool softeners) in order to minimize drug exposure to the fetus. Antacids may decrease the absorption of digoxin. Magnesium hydroxide should not be used in patients with renal failure unless their serum magnesium levels are being closely monitored. Rilpivirine: (Moderate) Concurrent administration of rilpivirine and antacids may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Potassium-sparing diuretics: (Moderate) Long-term use of potassium-sparing diuretics has been found to increase renal tubular reabsorption of magnesium which may cause hypermagnesemia in patients also receiving magnesium supplements, especially in patients with renal insufficiency. The simultaneous administration of an antacid with dasatinib decreased the Cmax and AUC of dasatinib by 58% and 55%, respectively. Diphenoxylate; Atropine: (Moderate) Diphenoxylate can decrease GI motility.
Closely monitor patients for changing analgesic requirements or adverse events. Delafloxacin: (Major) Administer oral delafloxacin at least 2 hours before or 6 hours after products that contain magnesium hydroxide. This interaction may be due to surface absorption of the antibacterial onto the antacid. Pexidartinib: (Moderate) Administer pexidartinib 2 hours before or after locally-acting antacids as concurrent administration may reduce pexidartinib exposure. Sotorasib: (Moderate) Avoid coadministration of sotorasib and gastric-reducing agents, such as antacids. Acetaminophen; Chlorpheniramine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. If aluminum or magnesium containing antacids are required during cefdinir therapy, cefdinir should be taken at least 2 hours before or after the antacid. Isoniazid, INH; Rifampin: (Moderate) Concomitant use of antacids and rifampin may decrease the absorption of rifampin. Acetaminophen; Dichloralphenazone; Isometheptene: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. 400 mg to 1,200 mg (5 mL to 15 mL of original strength suspension) as a single dose PO; may repeat up to 4 times per day if needed or as directed by a physician. Not for long-term use.
Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. Antacids may decrease the absorption of oral iron preparations. The effect of the antacids in this regard is not expected to have a significant effect on the ability of ezetimibe to lower cholesterol. Coadministration may impair absorption of sarecycline which may decrease its efficacy. Other orally administered aluminum or magnesium salts may also interfere with cefditoren absorption. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Ofloxacin: (Moderate) Administer magnesium hydroxide at least 2 hours before or 2 hours after ofloxacin. Mesalamine, 5-ASA: (Moderate) Do not coadminister mesalamine extended-release capsules (Apriso) with antacids. However, to limit any potential interaction, it would be prudent to administer ezetimibe at least 1 hour before or 2 hours after administering antacids. Nilotinib displays pH-dependent solubility with decreased solubility at a higher pH; therefore, concomitant use of nilotinib and antacids may result in decreased bioavailability of nilotinib. Acidifying Agents: (Major) Aluminum hydroxide and magnesium hydroxide (as well as other antacids, i.e. Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. Norfloxacin: (Major) Administer magnesium hydroxide at least 2 hours before or 2 hours after norfloxacin. The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. Rifampin: (Moderate) Concomitant use of antacids and rifampin may decrease the absorption of rifampin. Ciprofloxacin: (Moderate) Administer oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide.
Vitamin D analogs: (Moderate) Magnesium-containing antacids, such as magnesium hydroxide, should be used cautiously in patients receiving vitamin D analogs.
Dolutegravir: (Moderate) Administer dolutegravir 2 hours before or 6 hours after taking cation-containing gastrointestinal medications such as magnesium hydroxide. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. If these drugs must be used together, give glipizide at least 2 hours prior to the antacid. Pancrelipase: (Major) The effectiveness of gastrointestinal enzymes can be diminished with concurrent administration of antacids. Delavirdine: (Major) Coadministration of delavirdine with antacids results in decreased absorption of delavirdine. To help limit an interaction, do not take antacids at the same time as the amphetamine product. Instruct patients to avoid using antacids containing aluminum hydroxide or magnesium hydroxide within 2 hours of taking sotalol. Oral suspensions:Shake well prior to each use.For patients with constipation, follow dose with a full glass of water. Sotalol: (Moderate) Coadministration of antacids with sotalol reduces the Cmax and AUC of sotalol by 26% and 20%, respectively. Coadministration may result in decreased plasma concentrations of raltegravir, which may lead to HIV treatment failure or the development of viral resistance. Brompheniramine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Due to age-related changes in renal function, magnesium hydroxide should be used cautiously in geriatric patients. Acetaminophen; Chlorpheniramine; Dextromethorphan: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected.
Torsemide: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Monitor clinical response, and adjust propranolol dosage if needed to attain therapeutic goals. Antacids may decrease the absorption of oral iron preparations. This medication contains magnesium hydroxide. When the antacid is given 2 hours after rosuvastatin, no significant change in rosuvastatin plasma concentrations is observed. Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. consumer_milk_of_magnesia_magnesium_hydroxide. Acetaminophen; Hydrocodone: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Chloroquine: (Major) Chloroquine absorption may be reduced by antacids. Have patient drink a full glass of liquid with each dose. Phosphorus: (Moderate) Phosphate may bind magnesium salts and magnesium-containing antacids (e.g., magnesium carbonate, magnesium hydroxide) may limit phosphorus absorption or phosphorus may limit magnesium absorption.
Dosage should be modified depending on clinical response and degree of renal impairment. Cefuroxime: (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Budesonide; Formoterol: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. Octreotide: (Moderate) Coadministration of oral octreotide with antacids may require increased doses of octreotide. Captopril: (Major) Antacids can decrease the GI absorption of captopril if administered simultaneously. Do not take Milk of Magnesia if you are allergic to magnesium hydroxide or any ingredients contained in this drug. Daily doses of rifampin should be given at least 1 hour before the ingestion of antacids. Coadministration interferes with cefditoren absorption causing a decrease in the Cmax and AUC. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. The rate of absorption is not affected. What Is Exocrine Pancreatic Insufficiency? In general, it would be illogical to concurrently administer these drugs at the same time. Homatropine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Carbonic anhydrase inhibitors: (Moderate) Diuretics may interfere with the kidneys ability to regulate magnesium concentrations. Trospium: (Moderate) Antacids may inhibit the oral absorption of antimuscarinics. Raltegravir: (Major) Coadministration or staggered administration of aluminum and/or magnesium-containing antacids is not recommended during treatment with raltegravir. Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. Administer tipranavir and ritonavir 2 hours before or 1 hour after antacids. Frequent use of high doses of antacids should be avoided by patients receiving urinary acidifiers. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Bosutinib: (Moderate) Bosutinib displays pH-dependent aqueous solubility; therefore, concomitant use of bosutinib and antacids may result in decreased plasma exposure of bosutinib. Pazopanib: (Moderate) Separate administration of pazopanib and antacids by several hours if coadministration is necessary in order to avoid a reduction in pazopanib exposure, which may decrease efficacy. Mefenamic Acid: (Moderate) Ingestion of mefenamic acid with antacids is not recommended. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Acetaminophen; Dextromethorphan; Guaifenesin; Pseudoephedrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after the antacid.bb Gastrointestinal Enzymes: (Major) The effectiveness of gastrointestinal enzymes can be diminished with concurrent administration of antacids. Magnesium hydroxide is generally acceptable for use during pregnancy. Minocycline: (Moderate) Separate administration of minocycline and antacids by 2 to 3 hours.
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Antacids can impair the absorption of ketoconazole. However, doses may be divided throughout the day if needed.Do not administer concurrently with other oral medications due to possible interference with absorption; clinicians are advised to review drug interactions and advised times of dose separation to limit drug-drug interactions. Diazepam: (Moderate) The coadministration of diazepam with antacids results in delayed diazepam absorption due to the fact that antacids delay gastric emptying.
Antacids may decrease the absorption of oral iron preparations. Magnesium hydroxide should be used cautiously in patients with renal impairment or renal disease because of the increased risk of developing hypermagnesemia and magnesium toxicity. Naproxen; Esomeprazole: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Iron Salts: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Chlorpheniramine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption.
When used occasionally at recommended doses, magnesium hydroxide has not been found to produce teratogenic effects. In a single-dose crossover study in healthy volunteers, coadministration of tacrolimus and magnesium-aluminum-hydroxide resulted in a mean AUC increase of 21% and a 10% decrease in the mean tacrolimus Cmax, compared to tacrolimus administration alone. Hypermagnesemia has been reported in newborns whose mothers were using magnesium-containing antacid products chronically in high doses. Glyburide; Metformin: (Moderate) Antacids have been reported to increase the absorption of non-micronized glyburide, enhancing their hypoglycemic effects. In a drug interaction study, the AUC for raltegravir was decreased by 49% (90% CI, 35% to 60%), 51% (90% CI, 33% to 65%), and 30% (90% CI, 4% to 50%), when administered with, 2 hours before, and 2 hours after aluminum/magnesium hydroxide antacids, respectively. Acetaminophen; Caffeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. In drug interaction studies, simultaneous administration of bictegravir and antacids under fasted and fed conditions decreased the mean AUC of bictegravir by approximately 79% and 47%, respectively. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Separate administration of elvitegravir and antacids by at least 2 hours. Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. When needed, psyllium, docusate sodium or polyethylene glycol 3350 have minimal systemic absorption and can be considered for chronic constipation. Coadministration may impair absorption of omadacycline which may decrease its efficacy. Routine administration of bictegravir simultaneously with, or 2 hours after, antacids containing aluminum or magnesium is not recommended as the bioavailability of bictegravir may be reduced. Increasing the dose of erlotinib without modifying the administration schedule is unlikely to compensate for loss of exposure. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. Separate the administration of atazanavir and antacids to avoid the potential for interaction; give atazanavir 2 hours before or 1 hour after the antacid. (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. Coadministration may impair absorption of tetracycline which may decrease its efficacy. Captopril; Hydrochlorothiazide, HCTZ: (Major) Antacids can decrease the GI absorption of captopril if administered simultaneously. CrCl 25 mL/minute or more: Patients with renal impairment may be at risk of accumulating magnesium. If an antidiarrheal medication is needed, it would be wise to temporarily discontinue use of agents with laxative effects. If an antacid must be used while a patient is taking cefuroxime, administer the oral dosage of cefuroxime at least 1 hour before or 2 hours after the antacid. Patients on chronic mefloquine therapy might be at increased risk of adverse reactions, especially in patients with a neurological or psychiatric history. Concomitant use of oral budesonide and antacids, milk, or other drugs that increase gastric pH levels can cause the coating of the granules to dissolve prematurely, possibly affecting release properties and absorption of the drug in the duodenum. Fosamprenavir: (Moderate) The administration of an aluminum hydroxide and magnesium hydroxide containing antacid with fosamprenavir decreased fosamprenavir Cmax and AUC. Concomitant use of oral budesonide and antacids, milk, or other drugs that increase gastric pH levels can cause the coating of the granules to dissolve prematurely, possibly affecting release properties and absorption of the drug in the duodenum. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Separate the administration of atazanavir and antacids to avoid the potential for interaction; give atazanavir 2 hours before or 1 hour after the antacid. Naproxen; Pseudoephedrine: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Consult package label; maximum daily dosage is age and product specific. Acalabrutinib: (Moderate) Separate the administration of acalabrutinib and antacids by at least 2 hours if these agents are used together. Iron: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. As the clinical significance of this interaction is not known, the simultaneous administration of zalcitabine and magnesium-containing antacids is not recommended. Bumetanide: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Frequent use of these high dose antacids should be avoided in patients receiving urinary acidifiers. Closely monitor patients for changing analgesic requirements or adverse events. If concomitant use is unavoidable, take selpercatinib 2 hours before or 2 hours after administration of antacids. It is recommended that the administration of amprenavir and antacids be separated by at least 1 hour. Daily doses of rifampin should be given at least 1 hour before the ingestion of antacids. Check with your physician for additional information about side effects. In addition, antacids or other aluminum-containing agents should be used cautiously with sucralfate in patients with chronic renal failure due to the aluminum content of sucralfate and the potential for aluminum toxicity. Atazanavir; Cobicistat: (Major) It is recommended that antacids not be given at the some time as atazanavir because of potential interference with absorption of atazanavir. Atropine; Difenoxin: (Moderate) Diphenoxylate can decrease GI motility. In general, it may be prudent to avoid drugs such as antacids in combination with enteric-coated budesonide. Acetaminophen; Caffeine; Dihydrocodeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. Nilotinib: (Moderate) If concomitant use of these agents is necessary, administer the antacid approximately 2 hours before or approximately 2 hours after the nilotinib dose. Lansoprazole; Naproxen: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. The chemical structure of these antacids contains aluminum or magnesium which can bind cabotegravir in the GI tract. If the patient requires magnesium supplements or a magnesium-containing antacid, it may be wise to separate the administration of phosphates from magnesium-containing products. Fosinopril: (Moderate) Coadministration of antacids with fosinopril may impair absorption of fosinopril. What Are Warnings and Precautions for Magnesium Hydroxide?
Magnesium citrate should not be used chronically as a laxative due to the risk of hypermagnesemia. Sofosbuvir; Velpatasvir: (Moderate) Separate the use of antacids and velpatasvir administration by 4 hours. Neratinib: (Major) Administer neratinib at least 3 hours after administration of antacids if concomitant use is necessary due to decreased absorption and systemic exposure of neratinib; the solubility of neratinib decreases with increasing pH of the GI tract. Calcium products may form complexes with phenytoin that are nonabsorbable. Pancreatitis is inflammation of an organ in the abdomen called the pancreas. As these compounds enter the small intestine, they react with bicarbonate, forming magnesium carbonate and calcium carbonate, which are insoluble. Taking these drugs simultaneously may result in reduced oral bioavailability of cabotegravir. Avoid antacids within 1 hour before or after the bisacodyl dosage. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Cefpodoxime: (Moderate) Cefpodoxime proxetil requires a low gastric pH for dissolution; therefore, concurrent administration with medications that increase gastric pH (e.g., antacids) may decrease the bioavailability of cefpodoxime. Closely monitor patients for changing analgesic requirements or adverse events. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. To decrease the risk of virologic failure, avoid use of antacids for at least 2 hours before and at least 4 hours after administering rilpivirine. Closely monitor patients for changing analgesic requirements or adverse events. Separating adminisration times may help limit any possible interaction. Closely monitor patients for changing analgesic requirements or adverse events. Coadministration may impair absorption of tetracycline which may decrease its efficacy. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. [42282] [45899]. Generic:- Protect from freezing- Store at controlled room temperature (between 68 and 77 degrees F)Dulcolax:- Protect from freezing- Store at room temperatureEx-Lax:- Protect from freezing- Store at room temperatureFleet:- Storage information not provided in labelingPhillips Laxative:- Avoid excessive heat (above 104 degrees F)- Avoid excessive humidity- Store at room temperature (between 59 to 86 degrees F)Phillips Milk of Magnesia:- Protect from freezing- Store at room temperature. The federal Omnibus Budget Reconciliation Act (OBRA) regulates the use of medications in residents of long-term care facilities. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. Due to the serious nature of the complications associated with reflux in infants and neonates (such as failure to thrive, esophageal stricture, Barrett's esophagus, intraesophageal polyps, and associated pulmonary diseases) magnesium hydroxide should not be used as an antacid in infants or neonates without appropriate physician supervision. Patients who received concomitant oral sodium polystyrene sulfonate and non-absorbable cation-donating antacids and laxatives have developed systemic alkalosis. Coadministration may decrease the absorption of azithromycin which may decrease its efficacy. Magnesium and aluminum hydroxide antacids may increase the blood concentration of tacrolimus.
Do not take magnesium hydroxide within 2 hours of taking risedronate. Approximately 1530% of the magnesium chloride is absorbed and rapidly excreted by the kidneys in patients with normal renal function. Aluminum/magnesium hydroxide antacids decrease the AUC of mycophenolic acid by about 17% when given as mycophenolate mofetil. Phenytoin: (Moderate) Because the absorption of phenytoin suspension can be reduced by antacids containing magnesium, aluminum, or calcium, administration at the same time of day should be avoided when possible. Calcium carbonate is generally considered the first choice for antacid use during breast-feeding, but magnesium hydroxide is also considered compatible. Carbinoxamine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Acalabrutinib solubility decreases with increasing pH values; therefore, coadministration may result in decreased acalabrutinib exposure and effectiveness.
Acetaminophen; Dextromethorphan; Doxylamine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. In addition, some antacids like calcium carbonate, share the potential with the citrate salts for development of metabolic alkalosis, when given in higher dosage. to a friend, relative, colleague or yourself. Magnesium hydroxide is available over-the-counter (OTC) and as a generic. Moxifloxacin: (Major) Administer oral moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide.
Closely monitor patients for changing analgesic requirements or adverse events. Delafloxacin: (Major) Administer oral delafloxacin at least 2 hours before or 6 hours after products that contain magnesium hydroxide. This interaction may be due to surface absorption of the antibacterial onto the antacid. Pexidartinib: (Moderate) Administer pexidartinib 2 hours before or after locally-acting antacids as concurrent administration may reduce pexidartinib exposure. Sotorasib: (Moderate) Avoid coadministration of sotorasib and gastric-reducing agents, such as antacids. Acetaminophen; Chlorpheniramine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. If aluminum or magnesium containing antacids are required during cefdinir therapy, cefdinir should be taken at least 2 hours before or after the antacid. Isoniazid, INH; Rifampin: (Moderate) Concomitant use of antacids and rifampin may decrease the absorption of rifampin. Acetaminophen; Dichloralphenazone; Isometheptene: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. 400 mg to 1,200 mg (5 mL to 15 mL of original strength suspension) as a single dose PO; may repeat up to 4 times per day if needed or as directed by a physician. Not for long-term use.
Although the exact mechanism is not known, theoretically it may be due to alterations in gastric pH. Antacids may decrease the absorption of oral iron preparations. The effect of the antacids in this regard is not expected to have a significant effect on the ability of ezetimibe to lower cholesterol. Coadministration may impair absorption of sarecycline which may decrease its efficacy. Other orally administered aluminum or magnesium salts may also interfere with cefditoren absorption. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Ofloxacin: (Moderate) Administer magnesium hydroxide at least 2 hours before or 2 hours after ofloxacin. Mesalamine, 5-ASA: (Moderate) Do not coadminister mesalamine extended-release capsules (Apriso) with antacids. However, to limit any potential interaction, it would be prudent to administer ezetimibe at least 1 hour before or 2 hours after administering antacids. Nilotinib displays pH-dependent solubility with decreased solubility at a higher pH; therefore, concomitant use of nilotinib and antacids may result in decreased bioavailability of nilotinib. Acidifying Agents: (Major) Aluminum hydroxide and magnesium hydroxide (as well as other antacids, i.e. Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. Norfloxacin: (Major) Administer magnesium hydroxide at least 2 hours before or 2 hours after norfloxacin. The chemical structure of these GI drugs that contain polyvalent cations, such as magnesium hydroxide, can bind dolutegravir in the GI tract. Rifampin: (Moderate) Concomitant use of antacids and rifampin may decrease the absorption of rifampin. Ciprofloxacin: (Moderate) Administer oral ciprofloxacin at least 2 hours before or 6 hours after magnesium hydroxide.
Vitamin D analogs: (Moderate) Magnesium-containing antacids, such as magnesium hydroxide, should be used cautiously in patients receiving vitamin D analogs.
Dolutegravir: (Moderate) Administer dolutegravir 2 hours before or 6 hours after taking cation-containing gastrointestinal medications such as magnesium hydroxide. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. If these drugs must be used together, give glipizide at least 2 hours prior to the antacid. Pancrelipase: (Major) The effectiveness of gastrointestinal enzymes can be diminished with concurrent administration of antacids. Delavirdine: (Major) Coadministration of delavirdine with antacids results in decreased absorption of delavirdine. To help limit an interaction, do not take antacids at the same time as the amphetamine product. Instruct patients to avoid using antacids containing aluminum hydroxide or magnesium hydroxide within 2 hours of taking sotalol. Oral suspensions:Shake well prior to each use.For patients with constipation, follow dose with a full glass of water. Sotalol: (Moderate) Coadministration of antacids with sotalol reduces the Cmax and AUC of sotalol by 26% and 20%, respectively. Coadministration may result in decreased plasma concentrations of raltegravir, which may lead to HIV treatment failure or the development of viral resistance. Brompheniramine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Due to age-related changes in renal function, magnesium hydroxide should be used cautiously in geriatric patients. Acetaminophen; Chlorpheniramine; Dextromethorphan: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Torsemide: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Monitor clinical response, and adjust propranolol dosage if needed to attain therapeutic goals. Antacids may decrease the absorption of oral iron preparations. This medication contains magnesium hydroxide. When the antacid is given 2 hours after rosuvastatin, no significant change in rosuvastatin plasma concentrations is observed. Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. consumer_milk_of_magnesia_magnesium_hydroxide. Acetaminophen; Hydrocodone: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Chloroquine: (Major) Chloroquine absorption may be reduced by antacids. Have patient drink a full glass of liquid with each dose. Phosphorus: (Moderate) Phosphate may bind magnesium salts and magnesium-containing antacids (e.g., magnesium carbonate, magnesium hydroxide) may limit phosphorus absorption or phosphorus may limit magnesium absorption.
Dosage should be modified depending on clinical response and degree of renal impairment. Cefuroxime: (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Budesonide; Formoterol: (Moderate) Enteric-coated budesonide granules dissolve at a pH more than 5.5. Octreotide: (Moderate) Coadministration of oral octreotide with antacids may require increased doses of octreotide. Captopril: (Major) Antacids can decrease the GI absorption of captopril if administered simultaneously. Do not take Milk of Magnesia if you are allergic to magnesium hydroxide or any ingredients contained in this drug. Daily doses of rifampin should be given at least 1 hour before the ingestion of antacids. Coadministration interferes with cefditoren absorption causing a decrease in the Cmax and AUC. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. The rate of absorption is not affected. What Is Exocrine Pancreatic Insufficiency? In general, it would be illogical to concurrently administer these drugs at the same time. Homatropine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Carbonic anhydrase inhibitors: (Moderate) Diuretics may interfere with the kidneys ability to regulate magnesium concentrations. Trospium: (Moderate) Antacids may inhibit the oral absorption of antimuscarinics. Raltegravir: (Major) Coadministration or staggered administration of aluminum and/or magnesium-containing antacids is not recommended during treatment with raltegravir. Likewise, the dissolution of the coating of extended-release budesonide tablets (Uceris) is pH dependent. Administer tipranavir and ritonavir 2 hours before or 1 hour after antacids. Frequent use of high doses of antacids should be avoided by patients receiving urinary acidifiers. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Bosutinib: (Moderate) Bosutinib displays pH-dependent aqueous solubility; therefore, concomitant use of bosutinib and antacids may result in decreased plasma exposure of bosutinib. Pazopanib: (Moderate) Separate administration of pazopanib and antacids by several hours if coadministration is necessary in order to avoid a reduction in pazopanib exposure, which may decrease efficacy. Mefenamic Acid: (Moderate) Ingestion of mefenamic acid with antacids is not recommended. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Acetaminophen; Dextromethorphan; Guaifenesin; Pseudoephedrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. This decrease in bioavailability was about 5% when gabapentin was administered 2 hours after the antacid.bb Gastrointestinal Enzymes: (Major) The effectiveness of gastrointestinal enzymes can be diminished with concurrent administration of antacids. Magnesium hydroxide is generally acceptable for use during pregnancy. Minocycline: (Moderate) Separate administration of minocycline and antacids by 2 to 3 hours. Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Antacids can impair the absorption of ketoconazole. However, doses may be divided throughout the day if needed.Do not administer concurrently with other oral medications due to possible interference with absorption; clinicians are advised to review drug interactions and advised times of dose separation to limit drug-drug interactions. Diazepam: (Moderate) The coadministration of diazepam with antacids results in delayed diazepam absorption due to the fact that antacids delay gastric emptying.
Antacids may decrease the absorption of oral iron preparations. Magnesium hydroxide should be used cautiously in patients with renal impairment or renal disease because of the increased risk of developing hypermagnesemia and magnesium toxicity. Naproxen; Esomeprazole: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Iron Salts: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. Chlorpheniramine; Hydrocodone: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption.
When used occasionally at recommended doses, magnesium hydroxide has not been found to produce teratogenic effects. In a single-dose crossover study in healthy volunteers, coadministration of tacrolimus and magnesium-aluminum-hydroxide resulted in a mean AUC increase of 21% and a 10% decrease in the mean tacrolimus Cmax, compared to tacrolimus administration alone. Hypermagnesemia has been reported in newborns whose mothers were using magnesium-containing antacid products chronically in high doses. Glyburide; Metformin: (Moderate) Antacids have been reported to increase the absorption of non-micronized glyburide, enhancing their hypoglycemic effects. In a drug interaction study, the AUC for raltegravir was decreased by 49% (90% CI, 35% to 60%), 51% (90% CI, 33% to 65%), and 30% (90% CI, 4% to 50%), when administered with, 2 hours before, and 2 hours after aluminum/magnesium hydroxide antacids, respectively. Acetaminophen; Caffeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. In drug interaction studies, simultaneous administration of bictegravir and antacids under fasted and fed conditions decreased the mean AUC of bictegravir by approximately 79% and 47%, respectively. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Separate administration of elvitegravir and antacids by at least 2 hours. Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. When needed, psyllium, docusate sodium or polyethylene glycol 3350 have minimal systemic absorption and can be considered for chronic constipation. Coadministration may impair absorption of omadacycline which may decrease its efficacy. Routine administration of bictegravir simultaneously with, or 2 hours after, antacids containing aluminum or magnesium is not recommended as the bioavailability of bictegravir may be reduced. Increasing the dose of erlotinib without modifying the administration schedule is unlikely to compensate for loss of exposure. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. Separate the administration of atazanavir and antacids to avoid the potential for interaction; give atazanavir 2 hours before or 1 hour after the antacid. (Minor) Antacids may decrease the peak plasma concentration (Cmax) of total ezetimibe by 30%. Coadministration may impair absorption of tetracycline which may decrease its efficacy. Captopril; Hydrochlorothiazide, HCTZ: (Major) Antacids can decrease the GI absorption of captopril if administered simultaneously. CrCl 25 mL/minute or more: Patients with renal impairment may be at risk of accumulating magnesium. If an antidiarrheal medication is needed, it would be wise to temporarily discontinue use of agents with laxative effects. If an antacid must be used while a patient is taking cefuroxime, administer the oral dosage of cefuroxime at least 1 hour before or 2 hours after the antacid. Patients on chronic mefloquine therapy might be at increased risk of adverse reactions, especially in patients with a neurological or psychiatric history. Concomitant use of oral budesonide and antacids, milk, or other drugs that increase gastric pH levels can cause the coating of the granules to dissolve prematurely, possibly affecting release properties and absorption of the drug in the duodenum. Fosamprenavir: (Moderate) The administration of an aluminum hydroxide and magnesium hydroxide containing antacid with fosamprenavir decreased fosamprenavir Cmax and AUC. Concomitant use of oral budesonide and antacids, milk, or other drugs that increase gastric pH levels can cause the coating of the granules to dissolve prematurely, possibly affecting release properties and absorption of the drug in the duodenum. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Separate the administration of atazanavir and antacids to avoid the potential for interaction; give atazanavir 2 hours before or 1 hour after the antacid. Naproxen; Pseudoephedrine: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Consult package label; maximum daily dosage is age and product specific. Acalabrutinib: (Moderate) Separate the administration of acalabrutinib and antacids by at least 2 hours if these agents are used together. Iron: (Moderate) Doses of antacids and iron should be taken as far apart as possible to minimize the potential for interaction. As the clinical significance of this interaction is not known, the simultaneous administration of zalcitabine and magnesium-containing antacids is not recommended. Bumetanide: (Moderate) Loop diuretics may increase the risk of hypokalemia especially in patients receiving prolonged therapy with laxatives. Frequent use of these high dose antacids should be avoided in patients receiving urinary acidifiers. Closely monitor patients for changing analgesic requirements or adverse events. If concomitant use is unavoidable, take selpercatinib 2 hours before or 2 hours after administration of antacids. It is recommended that the administration of amprenavir and antacids be separated by at least 1 hour. Daily doses of rifampin should be given at least 1 hour before the ingestion of antacids. Check with your physician for additional information about side effects. In addition, antacids or other aluminum-containing agents should be used cautiously with sucralfate in patients with chronic renal failure due to the aluminum content of sucralfate and the potential for aluminum toxicity. Atazanavir; Cobicistat: (Major) It is recommended that antacids not be given at the some time as atazanavir because of potential interference with absorption of atazanavir. Atropine; Difenoxin: (Moderate) Diphenoxylate can decrease GI motility. In general, it may be prudent to avoid drugs such as antacids in combination with enteric-coated budesonide. Acetaminophen; Caffeine; Dihydrocodeine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Periodic antacid use should not be problematic as long as the antacid and enteric-coated naproxen administration are separated by at least 2 hours. Nilotinib: (Moderate) If concomitant use of these agents is necessary, administer the antacid approximately 2 hours before or approximately 2 hours after the nilotinib dose. Lansoprazole; Naproxen: (Minor) Concomitant administration of antacids can delay the absorption of naproxen. Monitor serum potassium levels to determine the need for potassium supplementation and/or alteration in drug therapy. Due to the formation of ionic complexes in the gastrointestinal tract, simultaneous administration results in lower elvitegravir plasma concentrations. The chemical structure of these antacids contains aluminum or magnesium which can bind cabotegravir in the GI tract. If the patient requires magnesium supplements or a magnesium-containing antacid, it may be wise to separate the administration of phosphates from magnesium-containing products. Fosinopril: (Moderate) Coadministration of antacids with fosinopril may impair absorption of fosinopril. What Are Warnings and Precautions for Magnesium Hydroxide?
Magnesium citrate should not be used chronically as a laxative due to the risk of hypermagnesemia. Sofosbuvir; Velpatasvir: (Moderate) Separate the use of antacids and velpatasvir administration by 4 hours. Neratinib: (Major) Administer neratinib at least 3 hours after administration of antacids if concomitant use is necessary due to decreased absorption and systemic exposure of neratinib; the solubility of neratinib decreases with increasing pH of the GI tract. Calcium products may form complexes with phenytoin that are nonabsorbable. Pancreatitis is inflammation of an organ in the abdomen called the pancreas. As these compounds enter the small intestine, they react with bicarbonate, forming magnesium carbonate and calcium carbonate, which are insoluble. Taking these drugs simultaneously may result in reduced oral bioavailability of cabotegravir. Avoid antacids within 1 hour before or after the bisacodyl dosage. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. Cefpodoxime: (Moderate) Cefpodoxime proxetil requires a low gastric pH for dissolution; therefore, concurrent administration with medications that increase gastric pH (e.g., antacids) may decrease the bioavailability of cefpodoxime. Closely monitor patients for changing analgesic requirements or adverse events. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. To decrease the risk of virologic failure, avoid use of antacids for at least 2 hours before and at least 4 hours after administering rilpivirine. Closely monitor patients for changing analgesic requirements or adverse events. Separating adminisration times may help limit any possible interaction. Closely monitor patients for changing analgesic requirements or adverse events. Coadministration may impair absorption of tetracycline which may decrease its efficacy. At higher pH values, iron is more readily ionized to its ferric state and is more poorly absorbed. [42282] [45899]. Generic:- Protect from freezing- Store at controlled room temperature (between 68 and 77 degrees F)Dulcolax:- Protect from freezing- Store at room temperatureEx-Lax:- Protect from freezing- Store at room temperatureFleet:- Storage information not provided in labelingPhillips Laxative:- Avoid excessive heat (above 104 degrees F)- Avoid excessive humidity- Store at room temperature (between 59 to 86 degrees F)Phillips Milk of Magnesia:- Protect from freezing- Store at room temperature. The federal Omnibus Budget Reconciliation Act (OBRA) regulates the use of medications in residents of long-term care facilities. Examples of compounds that may interfere with quinolone bioavailability include antacids that contain magnesium hydroxide. Due to the serious nature of the complications associated with reflux in infants and neonates (such as failure to thrive, esophageal stricture, Barrett's esophagus, intraesophageal polyps, and associated pulmonary diseases) magnesium hydroxide should not be used as an antacid in infants or neonates without appropriate physician supervision. Patients who received concomitant oral sodium polystyrene sulfonate and non-absorbable cation-donating antacids and laxatives have developed systemic alkalosis. Coadministration may decrease the absorption of azithromycin which may decrease its efficacy. Magnesium and aluminum hydroxide antacids may increase the blood concentration of tacrolimus.
Do not take magnesium hydroxide within 2 hours of taking risedronate. Approximately 1530% of the magnesium chloride is absorbed and rapidly excreted by the kidneys in patients with normal renal function. Aluminum/magnesium hydroxide antacids decrease the AUC of mycophenolic acid by about 17% when given as mycophenolate mofetil. Phenytoin: (Moderate) Because the absorption of phenytoin suspension can be reduced by antacids containing magnesium, aluminum, or calcium, administration at the same time of day should be avoided when possible. Calcium carbonate is generally considered the first choice for antacid use during breast-feeding, but magnesium hydroxide is also considered compatible. Carbinoxamine; Hydrocodone; Pseudoephedrine: (Minor) Concurrent use of hydrocodone with strong laxatives that rapidly increase gastrointestinal motility, such as magnesium hydroxide, may decrease hydrocodone absorption. Acalabrutinib solubility decreases with increasing pH values; therefore, coadministration may result in decreased acalabrutinib exposure and effectiveness.
Acetaminophen; Dextromethorphan; Doxylamine: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. In addition, some antacids like calcium carbonate, share the potential with the citrate salts for development of metabolic alkalosis, when given in higher dosage. to a friend, relative, colleague or yourself. Magnesium hydroxide is available over-the-counter (OTC) and as a generic. Moxifloxacin: (Major) Administer oral moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide.